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Cytogenex provides a fast and flexible Analytical and Research service using internationally accepted and validated methodologies. These activities allow for testing in the following categories:

  • Pharmaceutical/Nutraceutical/Food Supplement
  • Food analysis
  • Environmental monitoring
  • Stability
  • Anti-microbial activities of disinfectants/preservatives
  • Bio-Medical Research and Development

In addition to the above and to the provision of a trouble-shooting consultancy, Cytogenex also provides a consultancy service for the testing of pre-launch products for the food preparation and kitchen appliance industries.

Pharmaceutical/Nutraceutical/Food Supplement

Licensed and non-licensed products are analyzed for microbial contaminants using Methodologies approved by the MHRA. Results are presented to the customer by way of a Cytogenex Microbiology Report Form in a time period agreed with the customer.

Product identity, in the case of natural products, is addressed using in-house-developed DNA recognition techniques. Some of these techniques have been developed at the specific request of companies such as, Mycology Research Laboratories.

Other potential contaminants/active principals can be determined by in-house techniques, such as ELISA (Aflatoxin) and high performance thin layer chromatography and by HPLC/GC-MS/ ICP-MS and ICP spectrograph, provided in collaboration with the University of Hull as part of a pre-arranged project.

Food Analysis

Using principals developed under the guidelines of EU GMP for Pharmaceutical raw materials and products, microbiological analysis can performed for food products using methodologies provided by the customer. These methodologies are performed under the Accredited Quality Management System developed by Cytogenex. Allergens can be determined by methodologies involving antibody recognition (ELISA) and common genetic modifications can be screened using DNA techniques.

Environment Analysis

Microbial contamination of environmental samples can be performed using technologies available within the laboratory and the specific detection of pathogens can be performed using DNA techniques.

Cytogenex has developed an expertise for the detection of fungal agents, such as the Dry Rot fungus, Serpula lacrymans, using the technique of DNA-polymerase chain reaction (DNA-PCR). In instances of wood rot, it can sometimes be difficult to accurately identify the extent and spread of the Dry Rot fungus in a building environment. Cytogenex can provide an analysis of a small amount of material (less than 1g wood etc.) within 3 days of receipt of the sample.

Stability Monitoring

For the Pharmaceutical/Food/Healthcare and Cosmetics industries, it is important to obtain data concerning the length of time a product can be maintained at a normal shelf temperature before significant microbiological spoilage occurs. Cytogenex is able to perform stability studies at the temperature and relative humidity as instructed by the customer.

Anti-microbial Activities of Disinfectants/Preservatives

The ability of surface-acting and immersion-dependent disinfectants to adequately prevent the growth of microbial agents can be tested using methodologies that conform to international standards. Cytogenex has been working with companies, such as BioD Ltd., to develop Eco-friendly disinfecting agents for use in both domestic and industrial environments.

Bio-Medical Research and Development

Over the years that Cytogenex has been operating, the Company has maintained an interest in novel health-care-related therapeutic approaches. A number of projects have been undertaken and some of these have resulted in significant international publications:

  • The potential of the Sesame seed constituent Sesamol as a novel cancer therapeutic agent. Publications: Jacklin A, Ratledge C, Welham K, Bilko D, Newton CJ (2003). The sesame seed oil constituent, sesamol, induces growth arrest and apoptosis of cancer and cardiovascular cells. Ann. N. Y. Acad Sci. 1010: 374-380.
  • The role of steroid receptors and inflammatory mediators in tumour development. Publications: Bilko D, Trichomirowa M, Renner U, Staller GK, Ratledge C, Newton CJ (2004) The expression of ‘steroid superfamily’ receptors in meningiomas. Exp. Clin. Endocrinology and Diabetes. 112: 1055
  • Development of novel anticancer agents directed against breast cancer cell lines. Publications: Patole J, Padhye S, Padhye S, Newton CJ, Anson C, Powell AK (2004). Synthesis, characterization and in vitro anticancer activity of semicarbazone and thiosemicarbazone derivatives of salicylaldehyde and their copper complexes against human breast cancer cell line MCF-7. Ind. J. Chem. 43: 1654-1658. Dutta S, Padhye S, Indira Priyadarshini, Chris Newton (2005) Antioxidant and antiproliferative activity of curcumin semicarbazone. BMCL 15: 2738-2744.
  • Studies into the role of the enzyme, Poly (ADP-ribose) polymerase in the response of cells to oxidizing agents. Publications: Christopher J Newton, Dennis Bilko, Maria Tichomirowa, Ulrich Renner, and Günter K Stalla (2005) The role of poly (ADP-ribose)polymerase (PARP) in the response of pituitary tumor cells to reactive oxygen species (ROS) Endocrinology. 146(3):1119-27.
  • The role of statins in modulating the survival of vascular endothelial cells. Publications: Newton CJ, Ran G, Xie YX, Burgoyne CH, Adama IP, Abidia A, McCollum PT, Atkin SL. (2002). Statin-induced apoptosis of vascular endothelial cells is blocked by dexamethasone. J. Endocrinol.174 7-16. Xu SZ, Zhong W, Watson NM, Dickerson E, Wake J, Lindow S, Newton CJ, Atkin SL.Shang-Zhong X, Zhong W, Lindow S, Newton C, Atkin SL. (2008) Bcl-2 upregulation mediates the protective effect of fluvastatin against oxidative damage in human vascular endothelial cells. J Thromb Haemost. 6(4): 692-700.
  • The role of inflammatory mediators in tumour development. Publications: Thesis. Denys Bilko. August 2008.
  • The role of Toll immune system receptors in tumour development. Publications: Newton and Bilko. In preparation.